- An article published in Circulation by a group of authors from the Duke Clinical Institute, some of whom are investigators and leaders in ADAPTABLE describes tensions between pragmatic clinical trial design and Good Clinical Practice (GCP) guidelines, which were established in 1996 to help ensure the safety of participants in clinical trials and the validity ...
- Congratulations to the REACHnet team for receiving the first IRB approval for the ADAPTABLE Aspirin Study.
- February 2016
In this feature of Ask ADAPTABLE, we speak with Dr. Laura Beskow, ADAPTABLE Co-investigator who, along with her team, led the development of the ADAPTABLE consent form.
Q: Why did ADAPTABLE need a new approach to consent form development?
LB: My work has been devoted to studying ethical issues in research and informed consent raises many ...
- A conversation with Laura M. Beskow, MPH, PhD, ADAPTABLE Co-Investigator, Duke University
A core aspiration of PCORnet is to redirect the culture of clinical research from researcher-directed to patient-driven. In this spirit, the Duke Clinical Research Institute’s Program for Empirical Bioethics, headed by Dr. Laura Beskow, developed a patient-centered informed consent process for the ADAPTABLE study. ...
- Dr. Matthew Roe, co-principal investigator of the ADAPTABLE study, talks about the rationale and process involved in posting the ADAPTABLE draft protocol for public review and comment and how the feedback received impacted the final protocol.
- In these videos, Dr. Matthew Roe and Dr. Schuyler Jones explore:
The unique and Innovative Elements of ADAPTABLE
Who is Involved with ADAPTABLE
The Role of Open Science and the Impact of ADAPTABLE
Clinician Engagement in ADAPTABLE
The Importance of ADAPTABLE to Clinicians
- Adrian Hernandez, MD, MHS, discusses the important questions to be answered by the ADAPTABLE aspirin dosage study and how it will be conducted faster and more efficiently using the data resources of PCORnet.
- Adrian Hernandez, MD, MHS, and his co-authors outline how the study has the potential to change how clinical trials are conducted.
An upcoming study comparing two doses of aspirin for secondary prevention of cardiovascular events in high-risk patients will answer an important clinical question while simultaneously testing a new approach to conducting pragmatic clinical trials. The ...
- Trust is central to the relationship between patients and their clinicians. It’s also essential to the relationship between patients and researchers if patients are to fully engage in clinical research. As the healthcare industry becomes more patient-centered, clinical researchers will need to work closely with patients to assist them in finding answers to critical health ...
- Based on a model of sharing knowledge, collaboration, and transparency, the ADAPTABLE draft protocol was made available for stakeholder review on June 26, 2015. Through professional, social media, and e-mail channels, the research community, patients, and the public were all invited to read the draft study protocol and complete a survey. Specific questions regarding key ...
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